ABSTRACT
Objective: To investigate the clinical significance and difference of peripheral blood circulating tumor cells (CTC) detection in the prognosis of patients with gastric cancer and colorectal cancer. Methods: The CTC in the peripheral blood of 32 patients with gastric cancer and 36 patients with colorectal cancer were detected by negative enrichment and imFISH technique, and the results were compared between the two groups. Results: There were 8 cases (25%) of CTC 2) were detected, and only 8 cases survived. The two groups differed significantly in survival (P=0.001). Twenty-eight cases (78%) of the patients with colorectal cancer were detected CTC 2 groups survived at the end of the follow-up. Six patients survived at the end of the follow-up. There was a significant difference between CTC 2 groups in colorectal cancer (P=0.044). The survival in gastric cancer and colorectal cancer was significantly different (P0.05). Conclusion: Negative enrichment and imFISH technique can be used to detect CTC of the peripheral blood of patients with gastric cancer and colorectal cancer. The prognosis of patients with elevated CTC is poor. It is worse in gastric cancer than in colorectal cancer.
ABSTRACT
Objective: To investigate the clinical significance and difference of peripheral blood circulating tumor cells (CTCs) detection in the prognosis of patients with gastric cancer and colorectal cancer. Methods: The CTCs in the peripheral blood of 32 patients with gastric cancer and 36 patients with colorectal cancer were detected by negative enrichment and imFISH technique, and the results were compared between the two groups. Results: There were 8 cases (25%) of CTCs 2 were detected, and only 8 cases survived. The two groups differed significantly in survival (P=0.001). 28 cases (78%) of the patients with colorectal cancer were detected CTCs 2 groups survived at the end of the follow-up. 6 patients survived at the end of the follow-up. There was a significant difference between CTCs 2 groups in colorectal cancer (P=0.044). The survival in gastric cancer and colorectal cancer was significantly different (P=0.000). The results of CTCs were not correlated with gender, age, lymph node metastasis, distant organ metastasis or pathological grade of patients with colorectal cancer and gastric cancer (all P>0.05). Conclusion: Negative enrichment and imFISH technique can be used to detect CTCs of the peripheral blood of patients with gastric cancer and colorectal cancer. The prognosis of patients with elevated CTCs is poor. Gastric cancer has a poorer prognosis than colorectal cancer.